Calpain

Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.

Also Known As:

Ca2+-Activated Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calpain I; Calpain II; Desminase; Ca2+ Activated Protease; Calcium Activated Neutral Protease; Calcium Activated Neutral Proteinase; Calcium Activated Protease; Calcium Dependent Neutral Protease; Calcium Dependent Neutral Proteinase; Neutral Protease, Calcium-Activated; Neutral Protease, Calcium-Dependent; Neutral Proteinase, Calcium-Activated; Neutral Proteinase, Calcium-Dependent; Protease, Ca2+-Activated; Protease, Calcium-Activated; Protease, Calcium-Activated Neutral; Protease, Calcium-Dependent Neutral; Proteinase, Calcium-Activated Neutral; Proteinase, Calcium-Dependent Neutral; Calcium-Activated Neutral Protease; Calcium-Dependent Neutral Proteinase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Cysteine Proteases: 1964
        Cysteine Endopeptidases: 4
        Calpain: 2312
      - Endopeptidases: 633
        Cysteine Endopeptidases: 4
        Calpain: 2312

P Kotla Selected Research

P Kotla Research Topics

Disease

Drug/Important Bio-Agent (IBA)